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Tryptase Level. Club cells contain tryptase which is believed to be responsible for cleaving the hemagglutinin surface protein of influenza A virus thereby activating it and causing the symptoms of flu. Mast cell tryptase MCT is a key diagnostic test for mastocytosis and anaphylaxis.
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In multivariate analysis the extent of urticaria was the best single predictor of plasma histamine levels and of either an elevated histamine or tryptase level. - Tryptase levels can also be significantly and persistently increased with mastocytosis a rare group of disorders associated with an abnormal increase in the number of mast cells. Mast cell tryptase MCT is a key diagnostic test for mastocytosis and anaphylaxis.
Serum Tryptase is a marker of mast cell degranulation.
Tryptase EC 342159 is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation. Tryptase levels can elevated in a variety of disease - from benign to malignant entities. In multivariate analysis the extent of urticaria was the best single predictor of plasma histamine levels and of either an elevated histamine or tryptase level. If baseline total serum tryptase levels exceed 20 ngmL systemic mastocytosis should be suspected.
